Persistent alterations in GABAA receptor binding and function after prenatal lorazepam administration in the chick

@article{Miller1989PersistentAI,
  title={Persistent alterations in GABAA receptor binding and function after prenatal lorazepam administration in the chick},
  author={Lawrence G. Miller and R. Beth Roy and Cheryl L. Weill and Fred A. Lopez},
  journal={Brain Research Bulletin},
  year={1989},
  volume={23},
  pages={171-174}
}
Behavioral abnormalities have been reported in young and adult animals exposed to benzodiazepines prenatally. The presence of neurochemical alterations in the GABAergic system after prenatal benzodiazepine exposure was assessed in a chick model which avoids prenatal and postnatal maternal effects. The GABAA receptor complex, the presumed site of benzodiazepine action, was altered in adult chickens previously exposed to lorazepam for 10 days in ovo. Binding was decreased at the putative chloride… CONTINUE READING

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