Persistent activity in the prefrontal cortex during working memory

  title={Persistent activity in the prefrontal cortex during working memory},
  author={C. Curtis and M. D’Esposito},
  journal={Trends in Cognitive Sciences},
  • C. Curtis, M. D’Esposito
  • Published 2003
  • Psychology, Medicine
  • Trends in Cognitive Sciences
  • The dorsolateral prefrontal cortex (DLPFC) plays a crucial role in working memory. Notably, persistent activity in the DLPFC is often observed during the retention interval of delayed response tasks. The code carried by the persistent activity remains unclear, however. We critically evaluate how well recent findings from functional magnetic resonance imaging studies are compatible with current models of the role of the DLFPC in working memory. These new findings suggest that the DLPFC aids in… CONTINUE READING
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