Persistent activity in a cortical-to-subcortical circuit: bridging the temporal gap in trace eyelid conditioning.

@article{Siegel2012PersistentAI,
  title={Persistent activity in a cortical-to-subcortical circuit: bridging the temporal gap in trace eyelid conditioning.},
  author={Jennifer J Siegel and Brian E. Kalmbach and Raymond A Chitwood and Michael D. Mauk},
  journal={Journal of neurophysiology},
  year={2012},
  volume={107 1},
  pages={50-64}
}
We have addressed the source and nature of the persistent neural activity that bridges the stimulus-free gap between the conditioned stimulus (CS) and unconditioned stimulus (US) during trace eyelid conditioning. Previous work has demonstrated that this persistent activity is necessary for trace eyelid conditioning: CS-elicited activity in mossy fiber inputs to the cerebellum does not extend into the stimulus-free trace interval, which precludes the cerebellar learning that mediates conditioned… CONTINUE READING