Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma.

@article{Gagliardo2003PersistentAO,
  title={Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma.},
  author={Rosalia P Gagliardo and Pascal Chanez and M. -C. Mathieu and Andreina Bruno and Giorgia Costanzo and Claire Gougat and Isabelle Vachier and Jean Bousquet and Giovanni Bonsignore and Antonio Maurizio Vignola},
  journal={American journal of respiratory and critical care medicine},
  year={2003},
  volume={168 10},
  pages={1190-8}
}
The transcription factor nuclear factor-kappaB (NF-kappaB) is inactive when bound to its inhibitory protein IkappaBalpha. On cell stimulation with inflammatory signals, IkappaBalpha is phosphorylated by IkappaB kinases and subsequently degraded. Freed NF-kappaB then induces expression of cytokines such as granulocyte-macrophage colony-stimulating factor, interleukin-8, and regulated upon activation, normal T cell expressed and secreted. These mediators are overexpressed in asthma and are… CONTINUE READING