Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons.

@article{Herzog2001PersistentTN,
  title={Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons.},
  author={Raimund I. Herzog and Theodore R. Cummins and Stephen G. Waxman},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 3},
  pages={1351-64}
}
Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent at negative potentials. To investigate the possible contributions of this TTX-R persistent (TTX-RP) current to neuronal excitability, we carried out computer simulations using… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
117 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 117 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Spinal sensory neurons express multiple sodium channel a-subunit mRNAs.Mol Brain

  • JA BLACK, SD DIB-HAJJ, +4 authors SG. WAXMAN
  • 1996
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…