Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS.

@article{Xu2015PersistentSI,
  title={Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS.},
  author={Huanbin Xu and Xiaolei Wang and Naomi Malam and Andrew A Lackner and Ronald S Veazey},
  journal={Journal of immunology},
  year={2015},
  volume={195 9},
  pages={
          4351-7
        }
}
CD4(+) T follicular helper (Tfh) cells are critical for the generation of humoral immune responses to pathogenic infections, providing help for B cell development, survival, and affinity maturation of Abs. Although CD4(+) Tfh cells are reported to accumulate in HIV or SIV infection, we found that germinal center Tfh cells, defined in this study as CXCR5(+)PD-1(HIGH)CD4(+) T cells, did not consistently accumulate in chronically SIV-infected rhesus macaques compared with those infected with less… CONTINUE READING
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