Persistent Sexual Side Effects after SSRI Discontinuation

  title={Persistent Sexual Side Effects after SSRI Discontinuation},
  author={Antonei B Csoka and Stuart Shipko},
  journal={Psychotherapy and Psychosomatics},
  pages={187 - 188}
  • A. Csoka, S. Shipko
  • Published 1 April 2006
  • Psychology, Medicine
  • Psychotherapy and Psychosomatics
Case 3 A.H., a 30-year-old male, was prescribed 50 mg q.d. sertraline for chronic depression and insomnia in 1999. Four to fi ve days after starting the medication, he noticed a severe drop in sexual desire, moderate erectile dysfunction, diffi culty reaching orgasm with a long refractory time, reduced ejaculate volume, and genital numbness. He continued to take the medication, hoping that the side effects would subside. Since they did not abate after 5 weeks, he discontinued the sertraline… 
Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors.
SSRIs can cause long-term effects on all aspects of the sexual response cycle that may persist after they are discontinued, and Mechanistic hypotheses including persistent endocrine and epigenetic gene expression alterations were briefly discussed.
Sexual Consequences of Post-SSRI Syndrome.
  • Y. Reisman
  • Psychology, Medicine
    Sexual medicine reviews
  • 2017
Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?
The present review will report the state of art of these two different pathologies and discuss, on the basis of the role exerted by three different neuromodulators such as dopamine, serotonin and neuroactive steroids, whether the persistent sexual dysfunction observed could be determined by common mechanisms.
Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases
Clinical reports of post-SSRI sexual dysfunction, post-finasteride syndrome and enduring sexual dysfunction following isotretinoin point to a legacy syndrome or syndromes comprising a range of disturbances to sexual function.
Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence
Post-market prevalence studies have found that Selective Serotonin Reuptake Inhibitor (SSRI) and Serotonin- Norepinephrine Reuptake Inhibitor (SNRI) sexual side effects occur at dramatically higher
Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship
The findings add to previous reports and support the existence of PSSD, which may not be fully explained by alternative nonpharmacological factors related to sexual dysfunction, including depression and anxiety.
A Paradigmatic Case of Postselective Serotonin Reuptake Inhibitors Sexual Dysfunction or Withdrawal After Discontinuation of Selective Serotonin Reuptake Inhibitors?
encephalitis, the patient received metilprednisolone and immunoglobulin. One week after immunotherapy, she continued with severe signs of deliriumand excited catatonia, despite treatment with
Antidepressants and sexual dysfunction: a history
  • D. Healy
  • Psychology, Medicine
    Journal of the Royal Society of Medicine
  • 2020
Persistent genital arousal disorder primarily affects women and is now linked to hormonal changes around the menopause as well as discontinuation from serotonin reuptake inhibitor drugs – which include many antibiotics, antihistamines and analgesics in addition to antidepressants.
Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap
The authors argue that all psychologists should be well-informed about sexual side effects risks of antidepressant medications, should routinely conduct a pre-medication baseline assessment of sexual functioning, and take an active role in the informed consent process.


[Sexual dysfunction with antidepressive agents. Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI].
Amineptine was shown to be an effective antidepressant in the patients studied, and did not cause secondary sexual dysfunction, and even improved the dysfunction that was present in some patients.
Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?
Emotional blunting may be an under-appreciated side-effect of SSRIs that may contribute to treatment non-compliance and/or reduced quality of life.
Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate.
While most side effects first occurred within the first 2 weeks of treatment, the majority of patients were still experiencing the same side effects at the time of interview, most notably blurred vision and sexual dysfunction.
Selective Serotonin-Reuptake Inhibitor–Induced Movement Disorders
SSRI use appears to be associated with the development of movement disorders, as either a direct result of the drug or exacerbation of an underlying condition, and potential predisposing factors may include the use of neuroleptics, existing neurologic diagnoses, or preexisting movement disorders.
Amygdala Volume Reductions in Pediatric Patients with Obsessive–Compulsive Disorder Treated with Paroxetine: Preliminary Findings
It is suggested that abnormal asymmetry of the amygdala may play a role in the pathogenesis of OCD and that paroxetine treatment may be associated with a reduction in amygdala volume.
Role of serotonin in feedback control of hypothalamic-pituitary-testicular complex in male rats.
It is drawn that brain serotoninergic neurons are involved in feedback mechanisms related to the control of hypothalamic-pituitary-testicular complex in rats with intact gonads.
Men and women differ in amygdala response to visual sexual stimuli
It is shown that the amygdala and hypothalamus are more strongly activated in men than in women when viewing identical sexual stimuli, and the human amygdala may also mediate the reportedly greater role of visual stimuli in male sexual behavior, paralleling prior animal findings.
Mechanisms and treatments of SSRI-induced sexual dysfunction.
SSRI-induced sexual dysfunction affects 30% to 50% or more of individuals who take these drugs for depression, and five approaches to treatment include conservative approaches such as wait and see, decrease dosage, and drug holidays.