Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.

@article{Corvinus2005PersistentSA,
  title={Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.},
  author={Florian Matthias Corvinus and Carina Orth and Richard Moriggl and Svetlana A. Tsareva and Stefan Wagner and Edith B Pfitzner and Daniela Baus and Roland Kaufmann and Lukas A. Huber and Kurt Zatloukal and Hartmut Beug and Peter Ohlschl{\"a}ger and Alexander C. Sch{\"u}tz and Karl-Juergen Halbhuber and Karlheinz Friedrich},
  journal={Neoplasia},
  year={2005},
  volume={7 6},
  pages={
          545-55
        }
}
Colorectal carcinoma (CRC) is a major cause of morbidity and mortality in Western countries. It has so far been molecularly defined mainly by alterations of the Wnt pathway. We show here for the first time that aberrant activities of the signal transducer and activator of transcription STAT3 actively contribute to this malignancy and, thus, are a potential therapeutic target for CRC. Constitutive STAT3 activity was found to be abundant in dedifferentiated cancer cells and infiltrating… CONTINUE READING

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