Persistent Na+ current and Ca2+ current boost graded depolarization of rat retinal amacrine cells in culture.

@article{Koizumi2001PersistentNC,
  title={Persistent Na+ current and Ca2+ current boost graded depolarization of rat retinal amacrine cells in culture.},
  author={Amane Koizumi and Shun Watanabe and Akimichi Kaneko},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 2},
  pages={
          1006-16
        }
}
Retinal amacrine cells are depolarized by the excitatory synaptic input from bipolar cells. When a graded depolarization exceeds the threshold level, trains of action potentials are generated. There have been several reports that both spikes and graded depolarization are sensitive to tetrodotoxin (TTX). In the present study, we investigated the contribution of voltage-gated currents to membrane depolarization by using rat GABAergic amacrine cells in culture recorded by the patch-clamp method… CONTINUE READING

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