Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro.

@article{Koizumi2008PersistentNA,
  title={Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-B{\"o}tzinger complex in vitro.},
  author={Hidehiko Koizumi and Jeffrey C. Smith},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 7},
  pages={1773-85}
}
A central problem in analyzing neural circuit function is establishing how intrinsic neuronal conductances contribute to the generation of network activity. We used real-time calcium activity imaging combined with whole-cell patch-clamp recording to analyze contributions of subthreshold conductances in the excitatory rhythm-generating network in the respiratory pre-Bötzinger complex (pre-BötC) of neonatal rat in vitro brainstem slice preparations. Voltage-clamp ramp recordings from imaged pre-B… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 54 references

Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2004
View 6 Excerpts
Highly Influenced

The TASK family: two-pore domain background K+ channels.

Molecular interventions • 2003
View 6 Excerpts
Highly Influenced

Potassium-channel closure taken to TASK

Trends in Neurosciences • 2000
View 4 Excerpts
Highly Influenced

Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 7 Excerpts
Highly Influenced

Pacemaker neurons and neuronal networks: an integrative view.

Current opinion in neurobiology • 2004
View 5 Excerpts
Highly Influenced

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