Persistent LTP without triggered protein synthesis

@article{Abbas2009PersistentLW,
  title={Persistent LTP without triggered protein synthesis},
  author={Abdul-Karim Abbas and Mikhail Dozmorov and Rui Li and Fen-Sheng Huang and Holger Wigstr{\"o}m},
  journal={Neuroscience Research},
  year={2009},
  volume={63},
  pages={59-65}
}
Protein synthesis is believed to be involved in stabilizing synaptic plasticity. Effects lasting longer than about 2-3h are considered to require synthesis of new proteins, implying a functional separation between early (E) and late (L) components. However, the issue of constitutive vs. new protein synthesis is still unclear, especially in young animals. Here, we examined the effects of two protein synthesis inhibitors, anisomycin and emetine, on long-term-potentiation (LTP) in CA1 area of… CONTINUE READING
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