Persistent High Serum Bicarbonate and the Risk of Heart Failure in Patients With Chronic Kidney Disease (CKD): A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study

@inproceedings{Dobre2015PersistentHS,
  title={Persistent High Serum Bicarbonate and the Risk of Heart Failure in Patients With Chronic Kidney Disease (CKD): A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study},
  author={Mirela Dobre and Wei Yang and Qiang Pan and Lawrence J. Appel and Keith Bellovich and Jing Chen and Harold I. Feldman and Michael J. Fischer and L. M. L. Van Ham and Thomas H. Hostetter and Bernard G. Jaar and Radhakrishna Reddy Kallem and Sylvia E. Rosas and Julia J Scialla and M Wolf and M. D. Mostafizar Rahman},
  booktitle={Journal of the American Heart Association},
  year={2015}
}
BACKGROUND Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of this study was to conduct a time-updated longitudinal analysis to evaluate the association of serum bicarbonate with long-term clinical outcomes: heart failure, atherosclerotic events, renal events (halving of estimated glomerular filtration rate [eGFR] or end-stage renal disease), and mortality. METHODS AND RESULTS Serum bicarbonate… CONTINUE READING
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