Persistent HIF-1alpha activation in gut ischemia/reperfusion injury: potential role of bacteria and lipopolysaccharide.

@article{Koury2004PersistentHA,
  title={Persistent HIF-1alpha activation in gut ischemia/reperfusion injury: potential role of bacteria and lipopolysaccharide.},
  author={Jadd Koury and Edwin A. Deitch and Hiroshi Homma and Billy Abungu and Pranoti Gangurde and Michael R. Condon and Q M Lu and Da-zhong Xu and Rena Feinman},
  journal={Shock},
  year={2004},
  volume={22 3},
  pages={270-7}
}
In both animal models of hemorrhagic shock and clinical settings, shock-induced gut ischemia has been implicated in the development of the systemic inflammatory response syndrome and distant organ injury, yet the factors transducing these events remain to be fully determined. Because hypoxia-inducible factor (HIF-1), a transcription factor composed of oxygen-labile HIF-1alpha and constitutive HIF-1beta subunits, regulates the physiologic/pathophysiologic response to hypoxia and ischemia, we… CONTINUE READING
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