Persistent Expression of FLAG-tagged Micro dystrophin in Nonhuman Primates Following Intramuscular and Vascular Delivery

@article{RodinoKlapac2010PersistentEO,
  title={Persistent Expression of FLAG-tagged Micro dystrophin in Nonhuman Primates Following Intramuscular and Vascular Delivery},
  author={Louise R. Rodino-Klapac and Chrystal L. Montgomery and William G Bremer and Kimberly M. Shontz and Vinod Malik and Nancy D. Davis and Spencer Sprinkle and Katherine J Campbell and Zarife Sahenk and Kelly Reed Clark and Christopher M Walker and Jerry R. Mendell and Louis G. Chicoine},
  journal={Molecular Therapy},
  year={2010},
  volume={18},
  pages={109 - 117}
}
Animal models for Duchenne muscular dystrophy (DMD) have species limitations related to assessing function, immune response, and distribution of micro- or mini-dystrophins. Nonhuman primates (NHPs) provide the ideal model to optimize vector delivery across a vascular barrier and provide accurate dose estimates for widespread transduction. To address vascular delivery and dosing in rhesus macaques, we have generated a fusion construct that encodes an eight amino-acid FLAG epitope at the C… CONTINUE READING

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