Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood

@inproceedings{Cardenas2017PersistentDM,
  title={Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood},
  author={Andres Cardenas and Sheryl L. Rifas-Shiman and Golareh Agha and Marie-France Hivert and Augusto A Litonjua and Dawn L. DeMeo and Xihong Lin and Chitra J. Amarasiriwardena and Emily Oken and Matthew W Gillman and Andrea A. Baccarelli},
  booktitle={Scientific Reports},
  year={2017}
}
Prenatal exposure to mercury, a known neurotoxic metal, is associated with lower cognitive performance during childhood. Disruption of fetal epigenetic programming could explain mercury’s neurodevelopmental effects. We screened for epigenome-wide methylation differences associated with maternal prenatal blood mercury levels in 321 cord blood DNA samples and examined the persistence of these alterations during early (n = 75; 2.9–4.9 years) and mid-childhood (n = 291; 6.7–10.5 years). Among males… CONTINUE READING