Persistence of tolerance to methamphetamine-induced monoamine deficits.

  title={Persistence of tolerance to methamphetamine-induced monoamine deficits.},
  author={Jonathan P. Danaceau and Cassandra E Deering and Jayme E Day and Stacy J Smeal and Kamisha L. Johnson-Davis and Annette E. Fleckenstein and Diana G. Wilkins},
  journal={European journal of pharmacology},
  volume={559 1},
Methamphetamine is a highly addictive and potent stimulant, the use of which has increased significantly in recent years. In addition to the severe behavioral and societal consequences associated with methamphetamine abuse, methamphetamine can cause persistent damage to monoaminergic nerve terminals in rats, as measured by either monoamine concentrations or activity of the rate limiting synthetic enzymes, tyrosine hydroxylase and tryptophan hydroxylase. Repeated, sub-neurotoxic doses of… CONTINUE READING
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