Persistence of platinum-ammine-DNA adducts in gonads and kidneys of rats and multiple tissues from cancer patients.

@article{Poirier1992PersistenceOP,
  title={Persistence of platinum-ammine-DNA adducts in gonads and kidneys of rats and multiple tissues from cancer patients.},
  author={Miriam C. Poirier and Eddie Reed and Charles L. Litterst and David R. Katz and Shalina Gupta-Burt},
  journal={Cancer research},
  year={1992},
  volume={52 1},
  pages={
          149-53
        }
}
  • Miriam C. Poirier, Eddie Reed, +2 authors Shalina Gupta-Burt
  • Published in Cancer research 1992
The persistence of platinum-DNA adducts was investigated using normal rats as well as tissues from cancer patients receiving either cisdiamminedichloroplatinum(II) (cisplatin) or diamminecyclobutanedicarboxylatoplatinum(II) (carboplatin) for cancer chemotherapy. These studies used an enzyme-linked immunosorbent assay, established with a rabbit anti-cisplatin-DNA that is specific for intrastrand platinum-DNA adducts. The gonads and kidneys of male and female rats, sites for antitumor activity… CONTINUE READING

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