Persistence of lysergic acid diethylamide in the plasma of human subjects

  title={Persistence of lysergic acid diethylamide in the plasma of human subjects},
  author={George K. Aghajanian and Oscar H. L. Bing},
  journal={Clinical Pharmacology \& Therapeutics},
Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determined serially over the subsequent 8 hours. LSD‐25 was found to be present in human plasma in relatively large quantities during the period of peak effect. The half‐life of LSD‐25 in human plasma was calculated to be 175 minutes. 

Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry.

The method was used to determine pharmacokinetic parameters for LSD after oral administration (1 microgram/kg) to a male volunteer and the apparent plasma half-life was determined to be 5.1 h.

The determination of LSD in human plasma following oral administration.

Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects

Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the “tissue” (outer) compartment, and the estimated half‐life for loss of LSD‐25 from the plasma compartment, based on the model, was 103 minutes compared with a half-life of 180 minutes calculated directly from plasma concentrations.

Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide

Glycinexylidide is a metabolite of lidocaine that is frequently present in µg/ml concentrations in the plasma of patients treated with lidocane infusions for 24 hr or more, and GX adversely affects the mental performance of normal subjects at plasma concentrations comparable to those found in patients.

Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects

The present pharmacokinetic data are important for the evaluation of clinical study findings and the interpretation of LSD intoxication, with moderate counterclockwise hysteresis.

Body fluid levels of lysergide (LSD).

Lysergic Acid Diethylamide Toxicity

D-lysergic acid diethylamide, or LSD, is a compound of the lysergamide class known for its powerful psychedelic effects on humans, and remains as the most researched hallucinogen.

Pharmacokinetics and subjective effects of 1P-LSD in humans after oral and intravenous administration.

Control oral and intravenous self-administrations of 100 μg 1P-LSD hemitartrate are reported in two human volunteers followed by analyses of urine and serum samples using a fully validated LC-MS/MS method which supports the prodrug hypothesis.




This first of several articles on the narcotic drug, Axelrod detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, and determined that it was almost completely metabolized by the body.


  • H. Osmond
  • Psychology
    Annals of the New York Academy of Sciences
  • 1957
The field of inquiry is limited by a definition that will prevent workers in this field from being overwhelmed with an inconveniently large poition of the pharmacopoeia, and this rough and ready guide excludes morphine, cocaine, atropine, and their derivatives.

Mescaline, LSD, psilocybin, and personality change.

... our normal waking consciousness ... is but one special type of consciousness, whilst all about it, parted from it by the filmiest of screens, there lie potential forms of consciousness entirely

Distribution and fate of C14_ labeled lysergic acid diethylamide (LSD-25) in the animal

  • body, Experientia
  • 1955

The distribution and metabolism of lysergic acid diethylamide, Ann

  • New York Acad Sc
  • 1957

Distribution and fate of C " labeled lysergic acid diethylamide (LSD-25) in the animal body, Experientia

  • 1955