Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians.

  title={Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians.},
  author={Andrea B. Maier and Saskia le Cessie and Corine de Koning-Treurniet and Johanna Blom and Rudi G J Westendorp and Diana van Heemst},
  journal={Aging cell},
  volume={6 1},
Earlier studies on human fibroblast cultures have demonstrated an inverse relationship between the total number of population doublings (PDs) and donor age. As more recent studies were unable to replicate these findings, we set out to analyze growth characteristics of fibroblast cultures from nonagenarians who represent the extreme of human lifespan. Therefore, we obtained skin biopsies from 68 participants of the Leiden 85-plus Study, all aged 90 years. None of the 68 strains failed to… CONTINUE READING

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A high response is not essential to prevent selection bias: Results from the Leiden 85-plus study

  • A. B. der Wiel, E. van Exel, +4 authors R. G. Westendorp
  • J. Clin. Epidemiol
  • 2002
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