Persistence of high-capacity adenoviral vectors as replication-defective monomeric genomes in vitro and in murine liver.

@article{Jager2009PersistenceOH,
  title={Persistence of high-capacity adenoviral vectors as replication-defective monomeric genomes in vitro and in murine liver.},
  author={Lorenz Jager and Anja Ehrhardt},
  journal={Human gene therapy},
  year={2009},
  volume={20 8},
  pages={883-96}
}
Liver-based gene therapy approaches demonstrated that high-capacity adenoviral vectors (HC-AdVs) can persist life-long in mice and for 2 years or longer in rats, dogs, and nonhuman primates. However, the molecular status of episomal HC-AdV DNA molecules and the mechanism of vector genome maintenance have not been analyzed. HC-AdV lacks all viral coding sequences including early gene region 4 (E4), which prevents concatemerization in wild-type adenovirus. Therefore, we addressed whether… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…