Persistence of haloperidol in human brain tissue.

@article{Kornhuber1999PersistenceOH,
  title={Persistence of haloperidol in human brain tissue.},
  author={J. Kornhuber and A. Schultz and J. Wiltfang and I. Meineke and C. Gleiter and R. Z{\"o}chling and K. W. Boissl and F. Leblhuber and P. Riederer},
  journal={The American journal of psychiatry},
  year={1999},
  volume={156 6},
  pages={
          885-90
        }
}
  • J. Kornhuber, A. Schultz, +6 authors P. Riederer
  • Published 1999
  • Psychology, Medicine
  • The American journal of psychiatry
  • OBJECTIVE After discontinuation of neuroleptic drugs, their antipsychotic and antiparkinsonian effects are still present for a prolonged period. It is not known whether the extended effects of neuroleptic drugs in humans are due to the continued presence of drug in brain tissue or to long-lasting drug-induced physiologic changes. The aim of this study was to directly examine haloperidol concentrations in human brain tissue in relation to drug-free time. METHOD Haloperidol concentrations were… CONTINUE READING

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    Clinical and biological outcomes of prolonged treatment with haloperidol in schizophrenia.

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