Persistence of haloperidol in human brain tissue.

@article{Kornhuber1999PersistenceOH,
  title={Persistence of haloperidol in human brain tissue.},
  author={J. Kornhuber and A. Schultz and J. Wiltfang and I. Meineke and C. Gleiter and R. Z{\"o}chling and K. Boissl and F. Leblhuber and P. Riederer},
  journal={The American journal of psychiatry},
  year={1999},
  volume={156 6},
  pages={
          885-90
        }
}
OBJECTIVE After discontinuation of neuroleptic drugs, their antipsychotic and antiparkinsonian effects are still present for a prolonged period. It is not known whether the extended effects of neuroleptic drugs in humans are due to the continued presence of drug in brain tissue or to long-lasting drug-induced physiologic changes. The aim of this study was to directly examine haloperidol concentrations in human brain tissue in relation to drug-free time. METHOD Haloperidol concentrations were… Expand
Neuroleptic drugs in the human brain
Region specific distribution of levomepromazine in the human brain
Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol
Effects of haloperidol, clozapine and olanzapine on the survival of human neuronal and immune cells in vitro
Clinical and biological outcomes of prolonged treatment with haloperidol in schizophrenia.
Haloperidol and clozapine decrease S100B release from glial cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Persistence of haloperidol in the brain.
Prolonged pharmacologic activity of neuroleptic drugs.
Therapeutic brain concentration of the NMDA receptor antagonist amantadine
Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs?
Reduced haloperidol in the post-mortem brains of haloperidol-treated patients
Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem.
Drug distribution between blood and brain as a determinant of antipsychotic drug effects
Blood to brain distribution of neuroleptics
Plasma haloperidol levels and clinical effects in schizophrenia and schizoaffective disorder.
...
1
2
3
4
...