Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS.

@article{Zaragoza2011PersistenceOG,
  title={Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS.},
  author={Melinda M. Zaragoza and Sumathi Sankaran-Walters and Don R. Canfield and Jason Hung and Enrique J. Martinez and Andr{\'e} Joseph Ouellette and Satya Dandekar},
  journal={Journal of immunology},
  year={2011},
  volume={186 3},
  pages={1589-97}
}
Gastrointestinal mucosa is an early target of HIV and a site of viral replication and severe CD4(+) T cell depletion. However, effects of HIV infection on gut mucosal innate immune defense have not been fully investigated. Intestinal Paneth cell-derived α-defensins constitute an integral part of the gut mucosal innate defense against microbial pathogens. Using the SIV-infected rhesus macaque model of AIDS, we examined the level of expression of rhesus enteric α-defensins (REDs) in the jejunal… CONTINUE READING

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