Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase.

@article{Pearson1983PersistenceOC,
  title={Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase.},
  author={Russell C. Pearson and Michael V Sofroniew and Augusto Claudio Cuello and Thomas S. Powell and Felix P Eckenstein and Margaret M. Esiri and G. K. Wilcock},
  journal={Brain research},
  year={1983},
  volume={289 1-2},
  pages={375-9}
}
Immunohistochemically identified cholinergic neurons in the basal nucleus of Meynert in a brain with SDAT have been compared with those in two age- and sex-matched normal brains. The numbers of such cells at carefully matched levels are not significantly lower, but the cells in SDAT are substantially smaller than in the normal basal nucleus. The persistence of shrunken cholinergic neurons in the basal nucleus in the diseased brain is similar to that seen in an experimental study of retrograde… CONTINUE READING