Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33.

@article{Christianson2015PersistenceOA,
  title={Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33.},
  author={Christina A Christianson and Nicholas P Goplen and Iram Zafar and Chaoyu Irvin and James T. Good and Donald R Rollins and Balachandra K. Gorentla and Weimin Liu and Magdalena M. Gorska and Hongwei Chu and Richard J. Martin and Rafeul Alam},
  journal={The Journal of allergy and clinical immunology},
  year={2015},
  volume={136 1},
  pages={59-68.e14}
}
BACKGROUND Asthma in a mouse model spontaneously resolves after cessation of allergen exposure. We developed a mouse model in which asthma features persisted for 6 months after cessation of allergen exposure. OBJECTIVE We sought to elucidate factors contributing to the persistence of asthma. METHODS We used a combination of immunologic, genetic, microarray, and pharmacologic approaches to dissect the mechanism of asthma persistence. RESULTS Elimination of T cells though antibody-mediated… CONTINUE READING
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