Persistence of altered 5-hydroxytryptamine turnover following hemibody X-irradiation in the rat distal colon.

@article{Ropenga2004PersistenceOA,
  title={Persistence of altered 5-hydroxytryptamine turnover following hemibody X-irradiation in the rat distal colon.},
  author={Anna Ropenga and Olivier Combes and Alain Chapel and Nina M. Griffiths},
  journal={International journal of radiation biology},
  year={2004},
  volume={80 6},
  pages={399-411}
}
PURPOSE Acute gastrointestinal responses to ionizing radiation exposure include a role for 5-hydroxytryptamine (5-HT), but it is not known whether involvement of 5-HT persists and contributes to late effects. The aim was to investigate the acute and later effects of lower hemibody irradiation on 5-HT turnover and the biological effect in the rat distal colon. MATERIALS AND METHODS Rats were exposed to 10 Gy lower hemibody X-radiation. 5-HT and 5-hydroxyindole acetic acid tissue levels were… CONTINUE READING