Persistence of airway hyperresponsiveness and viral antigen following respiratory syncytial virus bronchiolitis in young guinea-pigs.

@article{Riedel1997PersistenceOA,
  title={Persistence of airway hyperresponsiveness and viral antigen following respiratory syncytial virus bronchiolitis in young guinea-pigs.},
  author={Frank Riedel and B Oberdieck and H. J. Streckert and Stathis Philippou and T. Krusat and Wolfgang Marek},
  journal={The European respiratory journal},
  year={1997},
  volume={10 3},
  pages={639-45}
}
Respiratory syncytial virus (RSV) bronchiolitis in infancy is known to be followed by chronic respiratory symptoms and airway hyperresponsiveness in a subgroup of patients. To further investigate the pathogenesis of RSV-induced chronic airway pathology, we infected young guinea-pigs at 4 weeks of age with RSV applied as an aerosol (n=30), and control guinea-pigs with virus-free culture medium (n=24). Infection was confirmed by positive antibody titre to RSV after 6 weeks, and by typical… CONTINUE READING