Persistence of West Nile Virus in the Central Nervous System and Periphery of Mice

@inproceedings{Appler2010PersistenceOW,
  title={Persistence of West Nile Virus in the Central Nervous System and Periphery of Mice},
  author={Kim K. Appler and Ashley N Brown and Barbara S. Stewart and Melissa J. Behr and Valerie L. Demarest and Susan J. Wong and Kristen A Bernard},
  booktitle={PloS one},
  year={2010}
}
Most acute infections with RNA viruses are transient and subsequently cleared from the host. Recent evidence, however, suggests that the RNA virus, West Nile virus (WNV), not only causes acute disease, but can persist long term in humans and animal models. Our goal in this study was to develop a mouse model of WNV persistence. We inoculated immunocompetent mice subcutaneously (s.c.) with WNV and examined their tissues for infectious virus and WNV RNA for 16 months (mo) post-inoculation (p.i… CONTINUE READING
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