Persistence of Vaccine-Derived Polioviruses among Immunodeficient Persons with Vaccine-Associated Paralytic Poliomyelitis

@article{Khetsuriani2003PersistenceOV,
  title={Persistence of Vaccine-Derived Polioviruses among Immunodeficient Persons with Vaccine-Associated Paralytic Poliomyelitis},
  author={Nino Khetsuriani and D. Rebecca Prevots and Linda Quick and Melissa E. Elder and Mark Pallansch and Olen Kew and Roland W. Sutter},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={188 12},
  pages={
          1845-52
        }
}
To estimate long-term poliovaccine virus persistence among immunodeficient patients with vaccine-associated paralytic poliomyelitis (iVAPP), cases reported in the United States during 1975-1997 were reviewed, with subsequent follow-up and virological testing. Six (16.2%) of 37 subjects excreted poliovaccine viruses for > or =6 months. Partial genomic sequencing of their available poliovirus isolates showed considerable divergence from the prototype Sabin strain in all cases. Poliovirus… CONTINUE READING
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