Persistence of Toxoplasma gondii in the central nervous system: a fine‐tuned balance between the parasite, the brain and the immune system

@article{Blanchard2015PersistenceOT,
  title={Persistence of Toxoplasma gondii in the central nervous system: a fine‐tuned balance between the parasite, the brain and the immune system},
  author={N. Blanchard and I. Dunay and D. Schl{\"u}ter},
  journal={Parasite Immunology},
  year={2015},
  volume={37}
}
Upon infection of humans and animals with Toxoplasma gondii, the parasites persist as intraneuronal cysts that are controlled, but not eliminated by the immune system. In particular, intracerebral T cells are crucial in the control of T. gondii infection and are supported by essential functions from other leukocyte populations. Additionally, brain‐resident cells including astrocytes, microglia and neurons contribute to the intracerebral immune response by the production of cytokines, chemokines… Expand
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