Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence

  title={Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence},
  author={Audrey S. Bahrick},
  journal={The Open Psychology Journal},
  • A. Bahrick
  • Published 5 May 2008
  • Psychology
  • The Open Psychology Journal
Post-market prevalence studies have found that Selective Serotonin Reuptake Inhibitor (SSRI) and Serotonin- Norepinephrine Reuptake Inhibitor (SNRI) sexual side effects occur at dramatically higher rates than initially reported in pre-market trials. Prescribing and practice conventions rest on the untested assumption that individuals who develop sex- ual dysfunction secondary to SSRI and SNRI antidepressant medications return fully to their pre-medication sexual func- tioning baseline shortly… 

Post-SSRI Sexual Dysfunction: A Literature Review.

Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship

The findings add to previous reports and support the existence of PSSD, which may not be fully explained by alternative nonpharmacological factors related to sexual dysfunction, including depression and anxiety.

Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap

The authors argue that all psychologists should be well-informed about sexual side effects risks of antidepressant medications, should routinely conduct a pre-medication baseline assessment of sexual functioning, and take an active role in the informed consent process.

Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies.

The results showed substantial and lasting effects on sexual behaviour in rats after exposure to an SSRI early in life on important sexual outcomes.

Exposure to serotonin selective reuptake inhibitors or serotonin noradrenaline reuptake inhibitors and sexual dysfunction: Results from an online survey.

Different variables, represented by both emotional and sexual symptoms, accounted for the variability of the severity of the sexual dysfunction as well as of wellbeing.

Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives

  • M. Atmaca
  • Psychology
    Neuropsychiatric disease and treatment
  • 2020
SSRI-induced sexual dysfunction and new perspectives in the management of this problem were reviewed and it was reported that one in eight people have utilized one of the SSRIs in the past 10 years.

Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?

The present review will report the state of art of these two different pathologies and discuss, on the basis of the role exerted by three different neuromodulators such as dopamine, serotonin and neuroactive steroids, whether the persistent sexual dysfunction observed could be determined by common mechanisms.

Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications

The present overview aimed at analyzing the literature to illustrate withdrawal after decrease, discontinuation, or switch of psychotropic medications based on the drug class, finding that benzodiazepines should be substituted by medications that cause less dependence such as antidepressants and antipsychotics runs counter the available literature.

Female sexual dysfunction in patients treated with antidepressant-comparison between escitalopram and fluoxetine.

There was no significant difference in the risk of having FSD between patients treated with fluoxetine or escitalopram as defined in the fourth edition of Diagnostic and Statistical Manual of Mental Disorders.



Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone

It is likely that persistent post-treatment genital anesthesia and other sexual side effects are underreported, and physicians should be aware of this bothersome phenomenon.

[Major depressive disorder, antidepressants and sexual dysfunction].

  • J. Kinzl
  • Psychology
    Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater
  • 2009
There are some possibilities for treatment of anti-depressant induced sexual dysfunctions such as waiting for spontaneous remission, reducing the dosage level, substituting the offending drug with other antidepressants, drug holidays, or administration of a phosphodiesterase- 5-inhibitor.

Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors.

SSRIs can cause long-term effects on all aspects of the sexual response cycle that may persist after they are discontinued, and Mechanistic hypotheses including persistent endocrine and epigenetic gene expression alterations were briefly discussed.

Selective serotonin reuptake inhibitor-induced sexual dysfunction in adolescents: a review.

  • A. Scharko
  • Medicine, Psychology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2004
Although the incidences of nonsexual SSRI-induced adverse effects seemed to be similar for both adult and pediatric populations, only one male of 1,346 pediatric subjects receiving an SSRI reported sexual dysfunction.

Treatment-emergent changes in sexual function with selective serotonin reuptake inhibitors as measured with the Rush Sexual Inventory.

The Rush Sexual Inventory (RSI) is a comprehensive, succinct, patient-rated scale designed to provide an accurate depiction of premorbid, current, and followup changes in sexual function and satisfaction.

Male Sexual Side Effects Associated with Antidepressants: A Descriptive Clinical Study of 32 Patients

Male sexual side effects can occur randomly and involve any sexual phase randomly, and the treatment approaches are similar, regardless of the types of sexual dysfunction associated with antidepressants.

Prevalence of sexual dysfunction among newer antidepressants.

This is the first study to assess sexual dysfunction across the newer antidepressants using consistent methodology and a validated rating scale and overall, SSRIs and venlafaxine XR were associated with higher rates of sexual dysfunction than bupropion or nefazodone.

SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients.

There was a significant increase in the incidence of sexual dysfunction when physicians asked the patients direct questions when SD was spontaneously reported, and patients experienced substantial improvement in sexual function when the dose was diminished or the drug was withdrawn.

Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction.

Persistent Sexual Side Effects after SSRI Discontinuation

A 30-year-old male was prescribed 50 mg q.d. sertraline for chronic depression and insomnia in 1999 and noticed a severe drop in sexual desire, moderate erectile dysfunction, reaching orgasm with a long refractory time, reduced ejaculate volume, and genital numbness.