Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability.

@article{Brune2007PersistenceON,
  title={Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability.},
  author={Kay Brune},
  journal={Current medical research and opinion},
  year={2007},
  volume={23 12},
  pages={
          2985-95
        }
}
BACKGROUND Non-steroidal, anti-inflammatory drugs (NSAIDs) are still the most widely used drugs worldwide. The introduction of selective cyclooxygenase (COX)-2 inhibitors has led to compounds which appear less damaging to the gastrointestinal tract, but possibly more risky to the cardiovascular system than older drugs. None has as yet reached OTC-status. OBJECTIVE This situation necessitates an analysis of the characteristics of those older ones which - due to their relative safety - have… CONTINUE READING
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