Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report.

  title={Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report.},
  author={Emily Kainne Dokubo and Annika Wendland and Suzanne Mate and Jason T. Ladner and Esther L Hamblion and Philomena Raftery and David J Blackley and Anthony S Laney and Nuha Mahmoud and Gloria Wayne-Davies and Lisa E Hensley and Eric J. Stavale and Lawrence S. Fakoli and Christopher J. Gregory and Tai-Ho Chen and Augustine Koryon and Denise Roth Allen and Jennifer Mann and Andrew C. Hickey and John Saindon and Mehboob Badini and April Baller and P{\'e}ter Clement and Fatorma K Bolay and Yatta Wapoe and Michael R. Wiley and James Logue and Bonnie Dighero-kemp and Elizabeth S. Higgs and Alex Gasasira and Desmond E. Williams and Bernice Dahn and Francis N Kateh and Tolbert Nyenswah and Gustavo F. Palacios and Mosoka Fallah},
  journal={The Lancet. Infectious diseases},
  volume={18 9},

Continued risk of Ebola virus outbreak

  • A. Toit
  • Medicine
    Nature Reviews Microbiology
  • 2018
It is reported that the possible source of infection in this cluster was a female patient who survived Ebola virus disease in 2014 and was persistently infected with the virus or suffered recurrent disease and subsequently transmitted the virus to family members a year later.

Ebola Virus Infection Associated with Transmission from Survivors

VPDTe has increased the importance of Ebola survivor services and sustained surveillance and response capacity in regions with previously widespread transmission and source and route of transmission.

Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks.

Next-generation sequencing is used to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients, which indicate that the new outbreak was not the result of a new spillover event from an animal reservoir.

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop

A case of atypical Ebola virus disease in a nonhuman primate after treatment with a monoclonal antibody is described, and sequence analysis identified a single mutation in glycoprotein (GP) that not only resisted antibody-mediated neutralization but also increased viral growth kinetics and virulence.

Ebola virus disease

The results of a randomized clinical trial of investigational therapeutics for EVD demonstrated survival benefits from two monoclonal antibody products targeting the EBOV membrane glycoprotein, resulting in new strategies toward prevention of infection and optimization of clinical management, acute illness outcomes and attendance to the clinical care needs of patients.

Ebola virus infection

A severe, often fatal, zoonotic infection caused by a virus of the Filoviridae family (genus Ebolavirus); the lack of any specific antiviral treatment or approved vaccine makes treatment difficult.



Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995.

Ebola virus persistence was examined in body fluids from 12 convalescent patients by virus isolation and reverse transcription-polymerase chain reaction (RT-PCR) during the 1995 Ebola hemorrhagic

Molecular Evidence of Sexual Transmission of Ebola Virus.

The genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission of Ebola virus disease and provided evidence of sexual transmission of EBOV and evidence of the persistence of infective E BOV in semen for 179 days or more after the onset of EVD.

Reduced evolutionary rate in reemerged Ebola virus transmission chains

It is demonstrated that, similar to the March 2015 flare-up associated with sexual transmission, this new flares-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission.

Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995.

Ebola hemorrhagic fever (EHF) patients treated at Kikwit General Hospital during the 1995 outbreak were tested for viral antigen, IgG and IgM antibody, and infectious virus. Viral antigen could be

Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report

These data showed the long‐term presence of Ebola virus RNA in semen and declining persistence with increasing time after ETU discharge, as well as the risk of sexual transmission of EVD.

Laboratory diagnosis of Ebola virus disease

New developments in the diagnosis of EVD are reviewed, with a focus on Guinea, Liberia, and Sierra Leone.

Recurrence and reinfection--a new paradigm for the management of Ebola virus disease.

  • C. MacintyreA. Chughtai
  • Medicine
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2016