Persistence of Antigen in Nucleoprotein Fractions of Mouse Spleen Cells during Antibody Formation

@article{Friedman1963PersistenceOA,
  title={Persistence of Antigen in Nucleoprotein Fractions of Mouse Spleen Cells during Antibody Formation},
  author={Herman Friedman},
  journal={Nature},
  year={1963},
  volume={199},
  pages={502-503}
}
THE fate and distribution of antigenic determinants in immunized animals is largely unknown1. There has been much speculation and experimentation concerning persistence of antigen during the period of antibody formation, as well as possible relationship of persisting antigen to specific immunological tolerance2,3. Recent work has indicated that neonatal injections of soluble antigens derived from Shigella micro-organisms may result in specific immune unresponsiveness in young mice4,5. It was… CONTINUE READING

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