Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease.

@article{kerud2002PersephinoverexpressingNS,
  title={Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease.},
  author={Peter {\AA}kerud and Pontus C. Holm and Gonçalo Castelo-Branco and Kyle M. Sousa and Francisco J. Rodriguez and Ernest Arenas},
  journal={Molecular and cellular neurosciences},
  year={2002},
  volume={21 2},
  pages={205-22}
}
Persephin (PSP) is a neurotrophic factor of the GDNF family that has been found to promote the survival of multiple populations of neurons. In the present study we have examined: (1) the mechanism of action and the function of PSP on nigrostriatal dopamine neurons and (2) the therapeutic potential of PSP, delivered by neural stem cells (NSCs) in a model of Parkinson's disease. Interestingly we found that the prenatal ventral mesencephalon and the newborn striatum express high levels of PSP mRNA… CONTINUE READING

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