Perplexities of pertussis: recent global epidemiological trends and their potential causes

  title={Perplexities of pertussis: recent global epidemiological trends and their potential causes},
  author={D W Jackson and Pejman Rohani},
  journal={Epidemiology and Infection},
  pages={672 - 684}
SUMMARY Recent much-publicized increases in pertussis case reports in some countries with high vaccine coverage have raised concerns about its current and future control. The ubiquity of this trend, however, remains unexamined. In an attempt to paint a global picture, we used case counts to determine which countries experienced statistically significant trends in incidence over the past two decades and to map changes in incidence during this period. These data reveal that pertussis resurgence… 

The pertussis enigma: reconciling epidemiology, immunology and evolution

Pertussis, a highly contagious respiratory infection, remains a public health priority despite the availability of vaccines for 70 years. Still a leading cause of mortality in developing countries,

Deciphering the impacts of vaccination and immunity on pertussis epidemiology in Thailand

It is found that, in contrast to other settings, there is no evidence for pertussis resurgence in Thailand, with each model examined pointing to a substantial rise in herd immunity over the past 30 y.

Commentary: resolving pertussis resurgence and vaccine immunity using mathematical transmission models

It is proposed that mathematical transmission models play an essential role in helping to interpret the data and in closing knowledge gaps in pertussis epidemiology and that recent advances in statistical inference methods now allow to estimate key parameters, such as the nature and duration of vaccinal immunity, which have to date been difficult to quantify.

The Pertussis resurgence: putting together the pieces of the puzzle

  • R. LapidotC. Gill
  • Biology, Medicine
    Tropical Diseases, Travel Medicine and Vaccines
  • 2016
Recent data indicating that the immune responses induced by aP vaccines differ fundamentally from those induced by the whole cell pertussis (wP) vaccines, and do not lead to mucosal immunity, appears likely that differences in how the two categories of vaccines work, may be pivotal to the overall understanding of the pertussedis resurgence.

Pertussis immunity and epidemiology: mode and duration of vaccine-induced immunity

Mechanistic transmission models are used to examine regional time series incidence data from Italy in the period immediately following the introduction of acellular pertussis (aP) vaccine and identify key data gaps: sources of data that can supply the information needed to eliminate remaining uncertainties.

A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States

Evidence of a difference in efficacy andduration of protection between the two vaccine types, wP and aP (aP efficacy and duration lower than wP) is found, and future refinement of the model presented here will allow for an exploration of alternative vaccination strategies.

Phylodynamics of pertussis in the vaccine era: transition to re-emergence

A positive association between genetic diversity and incidence is shown which validates the hypothesis that the resurgence is associated with the expansion of more pathogenic strains and suggests large outbreaks are unlikely to be due to immune evasion and the vaccine switch cannot be contributing to increased pertussis incidence.

Estimating the Duration of Pertussis Immunity Using Epidemiological Signatures

A simple mathematical model is analyzed, exploring specifically the inter-epidemic period and fade-out frequency and finds it supports a period of natural immunity that is, on average, long-lasting (at least 30 years) but inherently variable.

What is new in pertussis?

With pertussis continuing to pose a serious threat to infants, and greatly affecting adolescents and adults, there remains a need to increase the awareness of physicians as to the growing pertussi problem, standardize diagnostic techniques, and implement various new vaccine strategies to enhance its control.

The decline and resurgence of pertussis in the US.

Epidemiology of pertussis.

Despite high coverage rates for primary immunization in infants and children, pertussis continues to be a global concern, with increased incidence widely noted, and a general shift in the age distribution of pertussedis toward older groups is highlighted.

Factors contributing to pertussis resurgence.

Findings are summarized and factors contributing to pertussis resurgence in immunized populations are discussed, including antigenic divergence has been found between vaccine strains and clinical isolates in many countries with high vaccination coverage.

Impact of vaccination and birth rate on the epidemiology of pertussis: a comparative study in 64 countries

It is concluded that both vaccine coverage and birth rate drive pertussis periodicity globally and that vaccination induces strong herd immunity effects.

Pertussis: increasing disease as a consequence of reducing transmission.

The past, present, and future of pertussis. The role of adults in epidemiology and future control.

In the context of current programs emphasizing adult immunization, consideration should be given to booster doses of diphtheria-tetanus-pertussis in adults, using component pertussis vaccines when they become available.

Epidemiological, clinical, and laboratory aspects of pertussis in adults.

  • J. Cherry
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1999
It is believed that B. pertussis circulation cannot be controlled by the present childhood immunization program, and acellular pertussedis vaccines make adolescent and adult booster immunization programs possible, and these could lead to a decrease in the circulation of the organism.

Recent developments in pertussis