Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types

  title={Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types},
  author={Rebecca A. Ihrie and Elizabeth E. Reczek and Jennifer S. Horner and Leili Khachatrian and Julien Sage and Tyler 8 Jacks and Laura Attardi},
  journal={Current Biology},
The induction of apoptosis by the p53 protein is critical for its activity as a tumor suppressor. Although it is clear that p53 induces apoptosis at least in part by direct transcriptional activation of target genes, the set of p53 target genes that mediate p53 function in apoptosis in vivo remains to be well defined. The Perp (p53 apoptosis effector related to PMP-22) gene is highly expressed in cells undergoing p53-dependent apoptosis as compared to cells undergoing p53-dependent G1 arrest… CONTINUE READING
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