Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.

  title={Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.},
  author={Jun Zhou and Kaixun Huang},
  journal={Toxicology and applied pharmacology},
  volume={241 1},
  • Jun Zhou, Kaixun Huang
  • Published 2009
  • Biology, Medicine
  • Toxicology and applied pharmacology
  • Accumulating evidence suggests that peroxynitrite (ONOO(-)) is involved in the pathogenesis of insulin resistance. In the current study, we investigated whether insulin resistance in vivo could be mediated by nitration of proteins involved in the early steps of the insulin signal transduction pathway. Exogenous peroxynitrite donated by 3-morpholinosydnonimine hydrochloride (SIN-1) induced in vivo nitration of the insulin receptor beta subunit (IRbeta), insulin receptor substrate (IRS)-1, and… CONTINUE READING
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