Peroxynitrite mediates active site tyrosine nitration in manganese superoxide dismutase. Evidence of a role for the carbonate radical anion.

@article{Surmeli2010PeroxynitriteMA,
  title={Peroxynitrite mediates active site tyrosine nitration in manganese superoxide dismutase. Evidence of a role for the carbonate radical anion.},
  author={Nur Basak Surmeli and Nadia K. Litterman and Anne-Frances Miller and John T Groves},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 48},
  pages={17174-85}
}
Protein tyrosine nitration has been observed in a variety of human diseases associated with oxidative stress, such as inflammatory, neurodegenerative, and cardiovascular conditions. However, the pathways leading to nitration of tyrosine residues are still unclear. Recent studies have shown that peroxynitrite (PN), produced by the reaction of superoxide and nitric oxide, can lead to protein nitration and inactivation. Tyrosine nitration may also be mediated by nitrogen dioxide produced by the… CONTINUE READING
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