Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats.

@article{Kagota2007PeroxynitriteII,
  title={Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats.},
  author={Satomi Kagota and Yukari Tada and Yoko Kubota and Namie Nejime and Yu Yamaguchi and Kazuki Nakamura and Masaru Kunitomo and Kazumasa Shinozuka},
  journal={Journal of cardiovascular pharmacology},
  year={2007},
  volume={50 6},
  pages={677-85}
}
SHR/NDmcr-cp (SHR-cp) rats display typical symptoms and features of the metabolic syndrome. We previously reported that endothelium-dependent relaxation decreases in the thoracic aortas of SHR-cp rats, despite increased nitric oxide (NO) production from the endothelium. In the present study, to search for the reasons for this contradiction, we investigated whether vascular abnormality could be reduced by treatment of SHR-cp rats with antihypertensive drugs; a calcium channel blocker (amlodipine… CONTINUE READING
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