Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.

@article{Lefer1997PeroxynitriteIL,
  title={Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.},
  author={David Joseph Lefer and Rosario G Scalia and Barry R. Campbell and Tareck O Nossuli and Reid Hayward and Michela Salamon and Jason Grayson and Allan M. Lefer},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 4},
  pages={684-91}
}
Peroxynitrite (ONOO-) anion, formed by the interaction of superoxide with nitric oxide (NO), has previously been implicated as a cytotoxic agent. However, the effects of this free radical species on neutrophil (PMN)-endothelial cell interactions is largely unknown. We investigated the direct actions of ONOO- on PMN adhesion to endothelial cells in vitro and in vivo, as well as the effects of ONOO- on PMN-mediated myocardial ischemia-reperfusion injury. In vitro, peroxynitrite (100-1,000 nM… CONTINUE READING
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Coronary vascular and antiplatelet effects of peroxynitrite in human tissues

  • D. D. Ku, S. Liu, J. Dai
  • Endothelium .
  • 1995

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