Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.

@article{Mihm2001PeroxynitriteIN,
  title={Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.},
  author={Michael J. Mihm and Christen M Coyle and Brandon L. Schanbacher and David M Weinstein and John Anthony Bauer},
  journal={Cardiovascular research},
  year={2001},
  volume={49 4},
  pages={798-807}
}
OBJECTIVE Oxidative stress is implicated in the initiation and progression of congestive heart failure, but the putative reactive species and cellular targets involved remain undefined. We have previously shown that peroxynitrite (ONOO(-), an aggressive biological oxidant and nitrating agent) potently inhibits myofibrillar creatine kinase (MM-CK), a critical controller of contractility known to be impaired during heart failure. Here we hypothesized that nitration and inhibition of MM-CK… CONTINUE READING