Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.

@article{Cover2005PeroxynitriteinducedMA,
  title={Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.},
  author={Cathleen Cover and Abdellah Mansouri and Tamara Raphael Knight and Mary Lynn Bajt and John J. Lemasters and Dominique Pessayre and Hartmut Jaeschke},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={315 2},
  pages={879-87}
}
Intracellular sources of peroxynitrite formation and potential targets for this powerful oxidant and nitrating agent have not been identified after acetaminophen (AAP) overdose. Therefore, we tested the hypothesis that peroxynitrite generated in mitochondria may be responsible for mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage. C3Heb/FeJ mice were treated with 300 mg/kg AAP and monitored for up to 12 h. Loss of mtDNA (assayed by slot blot hybridization) and substantial nDNA… CONTINUE READING

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