Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.

@article{Vauzour2008PeroxynitriteIF,
  title={Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.},
  author={David Vauzour and Giulia Ravaioli and Katherina Vafeiadou and Ana M Rodriguez-Mateos and Cristina Angeloni and Jeremy P. E. Spencer},
  journal={Archives of biochemistry and biophysics},
  year={2008},
  volume={476 2},
  pages={
          145-51
        }
}
Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-catecholamine conjugates may contribute. In the present study, peroxynitrite was observed to generate both 2-S- and 5-S-cysteinyl-dopamine and a dihydrobenzothiazine species, DHBT-1, following the reaction of dopamine with l-cysteine. The formation of 5-S-cysteinyl-dopamine and… CONTINUE READING
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