Peroxynitrite-induced changes of thiol groups in human blood platelets.

  title={Peroxynitrite-induced changes of thiol groups in human blood platelets.},
  author={Pawel Nowak and Beata Olas and Edward Bald and Rafał Głowacki and Barbara Wachowicz},
  volume={14 6},
In this study we investigated sulfhydryl and disulfide metabolism in blood platelets treated with peroxynitrite (ONOO-) at concentrations of 10, 100, and 1000 microM. In platelets incubated with peroxynitrite, a decrease of both protein and low molecular weight thiols (glutathione, cysteine and cysteinylglycine) was observed. The reduction of platelet free thiols caused by ONOO- was dose dependent. We found that peroxynitrite induces the oxidation of platelet free SH-groups. Platelets contain a… CONTINUE READING


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