Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease.

@article{Koppal1999PeroxynitriteinducedAI,
  title={Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease.},
  author={Tanuja Koppal and Jennifer L Drake and Servet M. Yatin and Brad Jordan and Sridhar Varadarajan and L Bettenhausen and David Butterfield},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 1},
  pages={310-7}
}
Peroxynitrite (ONOO ) is a highly reactive, oxidizing anion with a half-life of <1 s that is formed by reaction of superoxide radical anion with nitric oxide. Several reports of ONOO--induced oxidation of lipids, proteins, DNA, sulfhydryls, and inactivation of key enzymes have appeared. ONOO- has also been implicated as playing a role in the pathology of… CONTINUE READING