Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.

  title={Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.},
  author={Attila Borb{\'e}ly and Attila Toth and Istv{\'a}n {\'E}des and L{\'a}szl{\'o} Vir{\'a}g and Julius Gy Papp and Andr{\'a}s Varr{\'o} and Walter Paulus and Jolanda van der Velden and Ger J M Stienen and Zolt{\'a}n Papp},
  journal={Cardiovascular research},
  volume={67 2},
OBJECTIVE Peroxynitrite-mediated myocardial protein nitration has been associated with a depressed cardiac pump function. In the present study, an attempt was made to elucidate the molecular background of peroxynitrite-evoked alterations in the human myocardium. METHODS Isometric force generation was measured in permeabilized human ventricular myocytes and biochemical methods were employed to identify the proteins affected by peroxynitrite-induced nitrotyrosine formation. RESULTS The… CONTINUE READING

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Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts. Circulation 2001;104:1140–6

  • J van der Velden, LJ Klein, R Zaremba, NM Boontje, MA Huybregts, W Stooker
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