Peroxynitrite dominates sodium nitroprusside-induced apoptosis in human hepatocellular carcinoma cells

@inproceedings{Quan2017PeroxynitriteDS,
  title={Peroxynitrite dominates sodium nitroprusside-induced apoptosis in human hepatocellular carcinoma cells},
  author={Ying-yao Quan and Yu-Hong Liu and Chun-Mei Lin and Xiaoping Wang and Tong-sheng Chen},
  booktitle={Oncotarget},
  year={2017}
}
This study aims to explore which radicals dominate sodium nitroprusside (SNP)-induced cytotoxicity in human hepatocellular carcinoma (HCC) cells (HepG2 and Hep3B). Exposure of SNP to cell medium produced abundant nitric oxide (NO), superoxide anion (O2•-), hydrogen peroxide (H2O2) and iron ions. SNP potently induced caspases activation, mitochondrial membrane permeabilization and apoptosis in HCC cells. In Hep3B cells, pretreatment with NO scavenger (PTIO) did not prevent SNP-induced… CONTINUE READING