Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus.

  title={Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus.},
  author={Ming-Hui Zou and Richard Alan Cohen and Volker Ullrich},
  journal={Endothelium : journal of endothelial cell research},
  volume={11 2},
Macro and microvascular diseases are the principal causes of morbidity and mortality in patients with type I and II diabetes mellitus. Growing evidence implicates reactive nitrogen species (RNS), such as peroxynitrite (ONOO-), derived from nitric oxide (NO) and superoxide anion (O2*-), are important in diabetes. The mechanisms by which diabetes increases RNS, and those by which RNS modifies vascular function, are poorly understood. The authors recently discovered that physiologically relevant… CONTINUE READING


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