Peroxisomicine A1 (plant toxin-514) affects normal peroxisome assembly in the yeast Hansenula polymorpha.

  title={Peroxisomicine A1 (plant toxin-514) affects normal peroxisome assembly in the yeast Hansenula polymorpha.},
  author={R Vargas-Zapata and V Torres-Gonz{\'a}lez and Julio Sep{\'u}lveda-Saavedra and Alfredo Pi{\~n}eyro-L{\'o}pez and Karl B. Rechinger and Ineke Keizer-Gunnink and Jan A. K. W. Kiel and Marten van der Klei Veenhuis},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={37 2},
Previously we demonstrated that peroxisomicine A1 (T-514), a plant toxin isolated from Karwinskia species, has a deteriorating effect on the integrity of peroxisomes of methylotrophic yeasts. Here we describe two strains of Hansenula polymorpha, affected in the normal utilization of methanol as sole source of carbon and energy due to peroxisomicine A1 treatment. The two strains isolated (L17 and RV31) grew poorly on methanol, apparently due to malfunctioning of their peroxisomes. Moreover, the… CONTINUE READING
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