Peroxisomes compensate hepatic lipid overflow in mice with fatty liver.

  title={Peroxisomes compensate hepatic lipid overflow in mice with fatty liver.},
  author={Birgit Knebel and Sonja Hartwig and Jutta Haas and Stefan Lehr and Simon Goeddeke and Franciscus Susanto and Lothar Bohne and Sylvia Jacob and Cornelia Koellmer and Ulrike Nitzgen and Dirk M{\"u}ller-Wieland and Jorg Kotzka},
  journal={Biochimica et biophysica acta},
  volume={1851 7},
UNLABELLED Major causes of lipid accumulation in liver are increased import or synthesis or decreased catabolism of fatty acids. The latter is caused by dysfunction of cellular organelles controlling energy homeostasis, i.e., mitochondria. Peroxisomes also appear to be an important organelle in lipid metabolism of hepatocytes, but little is known about their role in the development of non-alcoholic fatty liver disease (NAFLD). To investigate the role of peroxisomes alongside mitochondria in… CONTINUE READING
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